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. 2009 Sep 1;14(10):2483–2494. doi: 10.1111/j.1582-4934.2009.00890.x

Fig 6.

Fig 6

Effect of candesartan or telmisartan but not amlodipine on norepinephrine-induced vasomotion in mesenteric arterioles. Long-term administration of angiotensin AT1 receptor antagonist telmisartan or candesartan or calcium channel blocker amlodipine reduces blood pressure in vivo. The angiotensin AT1 receptor antagonist telmisartan (5 mg/kg per day) or candisartan (4 mg/kg per day), calcium channel blocker amlodipine (10 mg/kg per day) or placebo were administered to SHR by gavage for 16 weeks. (A) Summary data for systolic blood pressure from SHR. (B) Summary data for the rhythmic oscillatory vasomotion in mesenteric arterioles from SHR after treatment with candesartan, telmisartan, or amlodipine for 16 weeks. Representative tracings of norepinephrine-induced vasomotion in mesenteric arterioles from SHR under control conditions (C), administration of amlodipine (D), candesartan (E) or telmisartan (F). **P < 0.01 compared with placebo by ANOVA.