Fig. 3.

Stretching increases mRNA expression of stress specific markers and induces release of ANP. (A) ANP release into the medium (n = 3–9). (B) ANP expression (n = 8–21). (C) BNP expression (n = 8–20). (D) GDF15 expression (n = 8–19). Data are expressed relative to control. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with unstretched control. ANP: atrial natriuretic peptide; BNP: brain natriuretic peptide; GDF15: growth differentiation factor-15; Rplp0: ribosomal protein, large, P0.