Fig 4.

Effects of chronic treatment with telmisartan on weight gain, food intake, serum parameters and fat pad weight in wild-type (WT) and PPAR-δ-deficient (PPAR-δ^−/−) mice. Mice were fed a regular diet (Cont) or regular diet plus telmisartan (Tel). (A), (B) Body weights were measured every 2 weeks throughout the experimental period. (C), Daily food intake per mouse was recorded during the first 10 days after the start of telmisartan administration. Fasting serum levels of glucose (D), insulin (E) and triglyceride (F) were examined using routine methods after 24 weeks’ administration. (G) Subcutaneous fat (Sub-fat) and visceral fat (Vis-fat) were isolated and weighed when mice were killed after 24 weeks’ administration. H The ratio of fat pad weight to whole body weight. *P < 0.05; **P < 0.01 compared with Cont (n= 10 for each group).