Fig 6.

Chronic telmisartan treatment enhances running endurance and remodels myofibres. Mice were fed a normal diet (Cont) or a normal diet plus telmisartan (Tel). During weeks 23–24 of the experimental period, running endurance and oxygen consumption of the wild-type mice (WT) and PPAR-δ-deficient mice (PPAR-δ^−/−) were analysed (n= 5 per group). Running endurance was estimated by the duration (A) and the distance (B) of the run. Oxygen consumption included basal (C) and post-exercise (D) conditions. After 24 weeks’ treatment, mice were killed and gastrocnemius muscle was isolated immediately. (E) Weight of gastrocnemius muscle. (F) The ratio of gastrocnemius muscle weight to whole body weight. Skeletal muscle fibre typing was performed with cryostat sections of the gastrocnemius muscle using the metachromatic dye-ATPase method. (G) Representative figures of fibre typing from four independent experiments were shown. Type I fibres were stained dark blue. (H) The percentage of type I fibres was calculated. *P < 0.01 versus Cont (n= 4 per group).