Skip to main content
. 2011 Jun 22;15(7):1603–1614. doi: 10.1111/j.1582-4934.2010.01144.x

Fig 8.

Fig 8

The expressions of PcG gene expression after c-MYC expression changes and c-MYC/HDAC2 expression in hAD- and hBM-MSCs. (A–C) The expression changes of PcG complex genes after c-MYC expression changes with or without HDAC2 siRNA treatment in RT-PCR. Most PcG genes expressions are increased after c-MYC overexpression and reduced after HDAC2 siRNA treatment. (D) Relative gene expression of PcG genes with real-time RT-PCR. PcG gene expressions are positively correlated with c-MYC and HDAC2 expression except of EDR1, EDR2 and RING1 expressions. (E, F) Western blot of c-MYC and HDAC2. (E) The expression pattern of HDAC2 match that of c-MYC expression pattern in hAD-MSCs. (F) The expression of HDAC2 is down-regulated after c-MYC inhibition and up-regulated after c-MYC overexpression in hBM-MSCs. VC: vehicle control infected hMSCs; ShM3: c-MYC knocked-down hMSCs; OvM: c-MYC overexpressing hMSCs.