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Cross-talk between PTX3 and endothelium. Different cell types produce PTX3 (1) and/or cytokines that stimulate PTX3 upregulation in endothelium (2). PTX3 may then stimulate directly endothelial cells in a paracrine/autocrine manner (3) or it can bind various endothelial effectors (4). This will affect endothelial cell functions and integrity.
