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. 2007 Jul 2;11(4):810–825. doi: 10.1111/j.1582-4934.2007.00074.x

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The levels of amyloid precursor protein (APP) (A–C) and presenilin-1 (PS1) (A, D and E) in the hippocampus (B and D) and cerebellum (A, C and E) of mice with transgenic expression of human soluble interleukin-1 receptor antagonist (hsIL-1ra) with homozygotic (Tg hsIL-1ra+/+) and heterozygotic (Tg hsIL-1ra+/−) genotype, and of wild type (WT) mice. Adult mice display higher levels of APP than young mice, both in the hippocampus (*P < 0.05) (B) and cerebellum (*P < 0.001) (C). In the male mice, APP levels are lower in Tg hsIL-1ra+/− mice than in WT mice (#P < 0.05) (A, C; adult mice). The above line in A shows a representative Western blot for APP, at the size of the full-length protein, in samples from the cerebellum of adult male mice. Regarding PS1 levels, young mice have higher levels than adult mice both in the hippocampus (*P < 0.001) (D) and cerebellum (*P < 0.001) (E). Tg hsIL-1ra+/− mice have lower levels of PS1 than adult WT in both males and females (#P < 0.05) (E; adult mice). The below line in A shows a representative Western blot for PS1, at the size of the full-length protein, in samples from the cerebellum of adult male mice.