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. 2007 Jul 2;11(4):810–825. doi: 10.1111/j.1582-4934.2007.00074.x

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Correlations between the levels of mouse interleukin-1β (mIL-1β) and human soluble interleukin-1 receptor antagonist (hsIL-1ra) (A, B), mouse interleukin-6 (mIL-6) (C), mouse tumour necrosis factor-a (mTNF-α) (D), amyloid precursor protein (APP) (E) and presenilin 1 (PS1) (F), respectively, in the cerebellum of mice with transgenic expression of hsIL-1ra with homozygotic (Tg hsIL-1ra^+/+) and heterozygotic (Tg hsIL-1ra^+/−) genotype, and of wild type (WT) mice, of young and adult age. No correlation was found between the levels of mIL-1β and hsIL-1ra (A). Labelling of the individual animals according to genotype illustrates the different levels of hsIL-1ra (B). Adult mice have higher levels of mIL-1β than young mice of all genotypes (A, B). A positive correlation was found between the levels of mIL-1β and those of mIL-6 in both young (r = 0.66, P < 0.001), and adult (r = 0.92, P < 0.001) mice (C), and between the levels of mIL-1β and those of mTNF-α in both young (r = 0.78, P < 0.001), and adult (r = 0.95, P < 0.001) mice (D). APP (E) and PS1 (F) levels display a well-defined clustering pattern according to the age of the animals, but no correlation with mIL-1β levels.