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Contact inhibition of A498. A498 cells were treated with endothelial membrane fragments or with monoclonal antibodies directed against alpha2, alpha3 and alpha5 integrins (20μg/ml each). After preincubation, tumour cells were added to immobilized collagen, laminin, or fibronectin. Adherent cells were counted after 60 min and mean values calculated (cells/mm2). *indicates significant difference to controls One representative of 6 experiments is shown.
