Table 1.

Effect of inhibitors of phospholipase A2 and arachidonic acid metabolism on H. pylori urease-induced platelet aggregation

Platelet pre-treatment	% platelet aggregation mean ± S.D. (N)
None	100.00 ± 10.24 (4)
Dexamethasone (50 μM)	62.64*± 6.06 (4)
Esculetin (500 μM)	55.00**± 6.06 (4)
Indomethacin (150 μM)	160.74***± 12.74 (4)
(300 μM)	313.26***± 3.78 (4)

Rabbit PRP suspensions in microwell plates were incubated for 2 min. at room temperature in the absence or in the presence of the indicated concentrations of the drugs and aggregation was triggered by addition of HPU (0.3 μM). Aggregation of platelets was monitored ever 11 sec. during 20 min. in a SpectraMax plate reader.

Values of P < 0.05^*, P < 0.01^** or P < 0.001^*** were considered statistically significant.