Table 1.
Studies reporting on SPT and sIgE and the prognosis of PEANUT allergy.
| Author | N | Study design | Diagnosis of food allergy | Age 1 | Follow-up period | Follow-up diagnosis | Resolution | SPT (mm) | sIgE (kUA/L) |
|---|---|---|---|---|---|---|---|---|---|
| Mudd et al. 2009 [39] | 28 | Retrospective chart review | OFC | 5 years | 2.8 years (range 0.7–10 years) | OFC if clinically indicated (time, exposure and symptom history since last OFC or sIgE) | 46% | Not predictive of tolerance | |
| Ho et al. 2008 [10] | 267 | Longitudinal | SPT ≥ 4 mm | <2 years | Reviewed every 1–2 years for up to 8 years. | OFC offered when SPT < 4 mm (<2 years old) or 8 mm (>2 years old) | 18% | Increase SPT ≥ 3 between 1 and 4 years of age is predictor of persistence SPT ≥ 6 before 2 years predictive of persistent allergy | sIgE ≥ 3 before 2 years predictive of persistent allergy |
| Nolan et al. 2007 [15] | 54 | Prospective | Clinical history or positive SPT/sIgE with no history of ingestion. Excluded if sIgE >10 kUA/L, reaction in previous 2 years or previous severe reaction | 6.3 years (range 3.7–14.8 years) | NR | OFC (irrespective of SPT however parents could opt-out if SPT ≥ 8 mm | 53% | SPT ≥ 7 mm, 93% PPV | |
| Perry et al. 2004 [14] | 173 | Retrospective chart review | Clinical history or SPT/sIgE with no history of ingestion | 4.8 years | NR | OFC (if clinically indicated or when sIgE 25% of previously reported 95% PPV) | 59% | <2, 50% probability of tolerance | |
| (range 1–43 years) | |||||||||
| Fleischer et al. 2003 [13] | 84 | Retrospective chart review | Clinical history and SPT/sIgE or OFC; or no ingestion but positive SPT/sIgE | >4 years | NR | OFC or DBPCFC if sIgE < 5 | 55% | sIgE < 2 more likely to develop tolerance than sIgE 2–5 kU/L | |
| Skolnick et al. 2001 [9] | 223 | Retrospective follow-up | Clinical history and positive SPT, sIgE or OFC; or positive SPT and sIgE but no ingestion | 1.5 years (2 months–15 years) | NR | OFC. sIgE > 20 assumed allergic sIgE > 10 and severe reaction, no OFC (138 not challenged) | 21.5% | sIgE ≥ 5 64% PPV and 61% NPV | |
| Hourihane et al. 1998 [40] | 30 | Case-control | Clinical history | 5 years (range 2–10 years) | NR | OFC if clinically indicated (recent non-eventful exposure or negative SPT) | 50% | SPT ≥ 6 100% PPV and 80% NPV | Not predictive of tolerance |
| Sampson 1989 [12] | 10 | Retrospective | DBPCFC | 7.9 years (range 3–18 years) | 1–3 years | DBPCFC or accidental ingestion | 20% | Not predictive of tolerance |
1 Age at diagnosis or entry into study; reported as mean or median (range); NR: not reported.