Table 2.
Studies reporting on SPT and sIgE and the prognosis of EGG allergy.
| Author | N | Study design | Diagnosis of food allergy | Age 1 | Period of follow-up | Follow-up diagnosis | Tolerance | SPT (mm) | sIgE (kUA/L) |
|---|---|---|---|---|---|---|---|---|---|
| Montesinos et al. 2010 [48] | 42 | Retrospective follow-up | Clinical history and positive SPT/sIgE and OFC | 15.7 months (range 8–27.5 months) | 49 months (range 15–118.6 months) | OFC annually unless reaction in previous 3 months and positive SPT/sIgE | 50% | ≤2 years: 1.37, 96% PPV 0.36, 66% NPV | |
| 2–3 years: 1.52, 100% PPV 0.54, 75% NPV | |||||||||
| 3–4 years: 1.35, 100% PPV 0.36, 75% NPV | |||||||||
| 4–5 years: 2.59, 100% PPV 0.96, 60% NPV | |||||||||
| >5 years: 1.84, 100% PPV 0.65, 100% NPV | |||||||||
| Dieguez et al. 2009 [20] | 157 | Retrospective follow-up | Clinical history and positive SPT or sIgE, or OFC | 2.5 years (range 1–16 years) | NR | DBPCFC | 36% | ≥7, 90% PPV, LR + 6.7 | ≥1.5 90% PPV, LR + 5.5 |
| ≥9, 96% PPV, LR + 12.3 | |||||||||
| Kim 2009 [41] | 106 | Retrospective | sIgE > 2 | <2 years | Median 49 months (range 23–132 months) | Home challenge test if sIgE < 1.5 or accidental ingestion without reaction | 58% | Peak sIgE not predictive of outcome | |
| Mudd 2009 [39] | 38 | Retrospective chart review | OFC | 5 years | 2.8 years | OFC when clinically indicated | 47% | Not predictive of tolerance | |
| Savage et al. 2007 [22] | 881 | Retrospective chart review | Clinical history or sIgE > 2 and no known exposure | 14 months (IQR 10, 23 months) | Median 59 months (range 5–285 months) | OFC if sIgE < 2 kUA/L | 68% | Rate of tolerance inversely related to peak sIgE. sIgE > 50 marker for persistent allergy | |
| Perry et al. 2004 [14] | 138 | Retrospective chart review | Clinical history or SPT/sIgE | NR | NR | OFC when clinically indicated or sIgE < 95% PPV | 57% | sIgE < 2 50% probability of tolerance | |
| Shek et al. 2004 [33] | 88 | Retrospective | DBPCFC | 6 months–17 years | Up to 10 years | DBPCFC | 32% | sIgE decrease by 50% in 12 months: 0.52 probability of tolerance | |
| sIgE decrease by 90% in 12 months: 0.78 probability of tolerance | |||||||||
| Boyano-martinez et al. 2002 [49] | 59 | Prospective | OFC (n = 35) or recent reaction and positive sIgE | <2 years | Median 32 months | OFC every 1–3 years depending on previous symptoms | 59% | SPT < 6 increased likelihood (HR) of tolerance by 3.74 (95% CI 1.60–8.74). | sIgE predicted tolerance only in children with cutaneous symptoms |
| Crespo et al. 1994 [43] | 40 | OFC | 1 year | 2.5 years | OFC | 38% | sIgE ≥ 1.2 kuA/L 92% PPV | ||
| Sampson 1989 [12] | 59 | Retrospective | DBPCFC | 7.9 years (range 3–18 years) | 1–3 years | DBPCFC or accidental ingestion | 24% | Not predictive of tolerance | |
| Ford 1982 [47] | 25 | DBPCFC | 17 months (range 6 months–10 years) | 2–2.5 years | OFC | 44% | Decreased in resolved allergy |
NR: not reported; IQR: interquartile range; HR: hazard ratio; 1 Age at diagnosis or entry into study; reported as mean or median (range).