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. Author manuscript; available in PMC: 2013 Nov 11.
Published in final edited form as: J Immunol. 2011 Apr 22;186(11):10.4049/jimmunol.1004007. doi: 10.4049/jimmunol.1004007

Figure 5. NK cells are recruited to MLNs and lung during resolution.

Figure 5

a Histograms show representative expression of CXCR3 and CD62L on NK cells (NKp46+CD3−) from MLNs, lung, PB and spleen at peak inflammation (day 18, gray), and resolution (day 21 (red). b Median fluorescence intensity (MFI) of CXCR3 and CD62L expression on NK cells from the MLNs, lung, PB and spleen. c After depletion of endogenous NK cells with aGM1, CFSE labelled donor NK cells were adoptively transferred (day 19) after exposure ex vivo to anti-CXCR3, anti-CD62L, a combination of both or control IgG and enumerated in recipient mouse tissues during resolution (day 21). d MLN total cells and BALF total cell counts and eosinophils from mice reconstituted with adoptively transferred NK cells. Fold change in cxcl9 expression in (e) MLNs and (f) lung during peak inflammation (day 18) and resolution (day 21) of airway inflammation in mice given vehicle or RvE1. Data (mean ± s.e.m) are representative of more than 3 independent experiments with n≥3 FVB mice in each group. * P <0.05 (day 18); # P <0.05 (percentage compared to IgG).