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By using siRNA for MMP-16 we could reduce MMP-16 protein levels (A), as quantified in (B). Both a blocking antibody for MMP-16 (C) as the siMMP-16 (D) reduced MMP-2 activation, as visualized by zymography (C, D). Both approaches resulted in a reduction in cell migration in a scratch assay as shown for the specific MMP-16 antibody (E) or by using siRNA knockdown of MMP-16 (F). Data are presented as mean ± S.E.M., N = 3 and *P < 0.05.
