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. 2012 Sep 26;16(10):2451–2460. doi: 10.1111/j.1582-4934.2012.01562.x

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Copyright © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd

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Fig 3 — Neuroprotective and neurorestorative effects of GDF5-CHO cells in two adult rat models of PD. (A) Outline of experiment to analyse the neuroprotective effect of GDF5-CHO cells in the 6-OHDA MFB lesion model of PD. (B) Amphetamine-induced rotational rates at 21 days post-surgery for each treatment group (n = 5 per group). (C) Survival of dopaminergic neurons in the SN at 28 days post-surgery expressed as the number of TH-positive neurons in the left SN as a percentage of those in the right. Data are expressed as mean ± SEM. ***P < 0.001 compared with control (lesion only) and mock-CHO groups, anova with post-hoc Tukey's test. (D) Outline of experiment to analyse the neurorestorative effect of GDF5-CHO cells in the 6-OHDA striatal lesion model of PD. (E) Amphetamine-induced rotational rates at 28 days post-surgery for each treatment group (n = 5 per group). (F) Survival of dopaminergic neurons in the SN at 35 days post-surgery, expressed as the number of TH-positive neurons in the left SN as a percentage of those in the right. Data are expressed as mean ± SEM. *P < 0.05 compared with control (lesion only), mock-CHO (SN) and mock-CHO (striatum) groups; anova with post-hoc Tukey's test.