Fig 4.

Prolongation of kidney allograft survival by hIL-2-Luffin P1. (A) Kidneys from male donor Wistar rats were transplanted into three groups (n= 6–10) of SD recipient rats, which were then injected with HBSS as control, or with hIL-2-Luffin P1 or Luffin P1 every 2 days till rejection occurred. Accumulative survival curves were plotted. Kaplan–Meier survival analysis indicated significant prolongation of survival in hIL-2-Luffin P1 groups (P= 0.001 versus control). (B) Histological comparison of sections of kidney grafts from recipients treated with HBSS (left panel) or hIL-2-Luffin P1 (right panel) at the 8-day post-transplantation time point. The structures of the allografts were almost completely destroyed with extensive necrosis (shown by the arrow) in the control group, whereas there were only some inflammatory cells in glomerular and interstitial tissues, with low degree of degeneration in epithelial cells of proximal and distal convoluted tubules in hIL-2-Luffin P1 group (haematoxylin and eosin ×200).