Table 1.
Effect of Minerval on cancer cell growth and mechanism of action
| Cell line | Cancer type | Mechanism of action* | Antitumoural effect† |
|---|---|---|---|
| PC3 | Prostate | PA | +++ |
| LNcaP | Prostate | A | +++ |
| MDA-MB-231 | Breast | A | ++ |
| M220 | Pancreas | A | ++ |
| L-1210 | Lymphoblastic leukaemia | A | +++ |
| Jurkat | Lymphoblastic leukaemia | A | +++ |
| HL-60 | Myeloblastic leukaemia | PA | +++ |
| HeLa | Cervix | A | +++ |
| HT-29 | Colon | A | ++ |
| C-6 | Brain-glioma‡ | P | +++ |
| SH-SY5Y | Brain-neuroblastoma | P | + |
| A549 | Lung | P | +++ |
| IMR90 | Non-tumour fibroblasts | None | −§ |
*
A, apoptosis induction; P, proliferation inhibition. PA, proliferation inhibition at lower concentrations and apoptosis induction at higher concentrations. Mechanisms based on the studies listed in the Results section.
†
+, cell growth inhibition; ++, cell growth arrest; +++, complete killing of tumour cells (data at 200 μM).
‡
All cell lines listed are derived from human cancers except for C-6 rat glioma cells.
§
No effects were observed; IC50 > 5,000 μM.