Table 2.
Effect of Minerval on gene expression in Jurkat and A549 cells
| Gene symbol | Gene/protein name | Jurkat cells* | A549 cells* | Cellular effects† |
|---|---|---|---|---|
| CASP6 | Caspase 6 | + | = | A |
| DATF1 | Death associated transcription factor 1 | + | = | A |
| MADD | MAP-kinase activating death domain | + | = | A |
| PDCD5 | Programmed cell death 5 | + | = | A |
| PRG1 | Proteoglycan 1 | + | = | A |
| STK4 | Serine/threonine kinase 4 | + | = | A |
| TIAL1 | TIA1 CG-associated RNA binding protein-like 1 | + | = | A |
| TNFSF8 | TNF (ligand) superfamily, member 8 | + | = | A |
| TP53I3 | Tumour protein p53 inducible protein 3 | + | = | A |
| DUSP5 | Dual specificity phosphatase 5 | + | + | D / Pi |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | = | + | A |
| BID | BH3 interacting domain death agonist | = | + | A |
| EPHA2 | EphA2 | = | + | D |
| HDAC5 | Histone deacetylase 5 | = | + | D / Pi |
| LIF | Leukaemia inhibitory (differentiation) factor | = | + | D |
| MYADM | Myeloid-associated differentiation marker | = | + | D |
| PPP1R15A | Protein phosphatase 1, inhibitory subunit 15A | = | + | A / Pi |
| RAI3 | Retinoic acid induced 3 | = | + | D / Pi |
| RIS1 | Ras induced senescence 1 | = | + | D |
| S100A2 | S100 calcium binding protein A2 | = | + | D / Pi |
| ABL1 | V-abl Abelson leukaemia oncogene homolog 1 | – | = | Pa |
| CCND1 | Cyclin D1 (PRAD1) | – | = | Pa |
| CDC25A y B | Cell division cycle 25A y B | – | = | Pa |
| CDK10 | Cyclin-dependent kinase 10 | – | = | Pa |
| CDK6 | Cyclin-dependent kinase 6 | – | = | Pa |
| CLK-2 | CDC-like kinase 2 | – | = | Pa |
| CRSP7 | Cofactor for Sp1 activation, subunit 7 | – | = | Pa |
| E2F2 | E2F transcription factor 2 | – | = | Pa |
| FOLR1 | Folate receptor 1 | – | = | Pa |
| MAP3K11 | MAP kinase kinase kinase 11 | – | = | Pa |
| RBL1 | Retinoblastoma-like 1 (p107) | – | = | Pa |
| CDCA8 | Cell division cycle associated 8 | – | – | Pa |
| MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | – | – | A / D / Pa |
| RBBP6 | Retinoblastoma binding protein 6 | – | – | A / D / Pa |
| CCNA2 | Cyclin A2 | = | – | D / Pa |
| CCNG1 | Cyclin G1 | = | – | Pa |
| ECT2 | Epithelial cell transforming sequence 2 oncogene | = | – | Pa |
| EIF5A y B | Eukaryotic translation initiation factor 5A y B | = | – | Pa |
| GSPT1 | G1 to S phase transition 1 | = | – | Pa |
*
Significant (P < 0.05) and marked (over 2-fold) increase (+) or decrease (−), or no significant changes (=), with respect to untreated cells.
†
Pathway(s) regulated by the gene: A, Apoptosis; P, cell proliferation inhibition (Pi) or activation (Pa); D, cell differentiation.