2.

Shuttling of GR-α between the cytoplasm and the nucleus and its transactivating or transrepressive activities. Possible sites of intervention, which may change the activity of GR-α are indicated by numbers. GR: glucocorticoid receptor; GREs: glucocorticoid-responsive elements; TFREs: transcription factor responsive elements; HSP: heat shock proteins; TF: transcription factor. ‘This article (figure) was published in Journal of Steroid Biochem. Mol. Biol. 85, T. Kino, MU De Martino, E. Charmandari, M. Mirani, GP. Chrousos, Tissue glucocorticoid resistance/hypersensitivity syndromes, 457–467, Copyright Elsevier 2003’.