2.
CaMKII inhibitor, KN93, inhibits CaMKII phospho-rylation and tonic force in response to PE.(A) Effect of KN93 versus an inactive congener, KN92 on PE(10−5 M)-induced increases in T287 phosphorylation at the late, 60 min.time-point.(B) Effect of KN93 versus that of an inactive congener, KN92 on PE-induced changes in T305 phosphorylation.(C) Effect of KN93 versus that of an inactive congener, KN92 on PE-induced increases in contractile force at the late, 60 min time point. In all cases, n= 6–10 separate animals. *, P<0.05; **P<0.01 compared to rest; NS, not significantly different.