FIGURE 2.

Transcriptional and post-transcriptional regulation of hepatic FA trafficking. Green arrows indicate sources of intracellular FA and red arrows indicate routes of FA disposal. AMPK, AMP-activated protein kinase; CHREBP, carbohydrate response element binding protein; CR, chylomicron remnant; FA, fatty acid; FOXA/O, forkhead box protein; FXR, farnesoid X receptor; HNF-4α, hepatocyte nuclear factor-4α LXR, liver X receptor; mTORC1, mammalian target of rapamycin complex 1; SIRT1, sirtuin 1; SREBP, sterol regulatory element binding protein.