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Activation of NF-kB p65 in the intestinal epithelium. Sepsis induced activation of NF-kB p65 in the intestinal epithelium as measured by a transcription factor assay (A). Similar results were seen when levels were assayed by Western blot in both sham (B) and septic mice (C). Ablation of Ikkß in the intestinal epithelium (Vil-Cre/Ikkßf/Δ) prevented activation of NF-kB p65 following induction of septic peritonitis. n=4-7/group.
