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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Crit Care Med. 2013 Oct;41(10):10.1097/CCM.0b013e31828a44ed. doi: 10.1097/CCM.0b013e31828a44ed

Figure 3.

Figure 3

Sepsis-induced intestinal epithelial apoptosis is exacerbated in mice lacking functional enterocyte NF-kB. Intestinal apoptosis was quantified in crypt (A and B) and villus (C and D) epithelium via H&E staining (A and C) and active caspase-3 staining (B and D). Septic WT mice exhibited increased epithelial apoptosis compared to shams by both methods, while septic Vil-Cre/Ikkßf/Δ mice exhibited exacerbated epithelial apoptosis compared to septic WT mice. n=9-12/group. Representative histomicrographs (E) are shown for sham and septic WT and Vil-Cre/Ikkßf/Δ mice stained for active caspase 3. Active caspase 3 staining in the crypt epithelium appears brown.