Table 2. Hepcidin and iron parameters at cohort enrollment in HIV-infected patients with (cases) or without (controls) incident TB.
| Cases groupa | Matched controls | P b | Unmatched controls | P c | P d | |
| n = 42 | n = 42 | n = 43 | ||||
| Hepcidin, nM | 9.9 (5.0–18.2) | 7.2 (2.9–10.2) | 0.035 | 4.4 (2.0–7.9) | <0.001 | 0.06 |
| Ferritin, µg/l | 680.5 (245.0–1439.0)34 | 297.0 (175.0–462.0)37 | 0.006 | 213.5 (74.3–358.0)36 | <0.001 | 0.09 |
| sTfR, mg/l | 1.4 (1.1–2.2)34 | 1.4 (1.2–1.9)37 | 0.61 | 1.3 (1.1–1.6)36 | 0.13 | 0.28 |
| Serum iron, µmol/l | 7.0 (5.0–11.0)7 | 10.5 (6.3–17.5)16 | 0.27 | 16.0 (10.0–27.0)15 | 0.03 | 0.13 |
| TIBC, µmol/l | 39.0 (38.0–54.0)7 | 51.0 (43.3–59.8)16 | 0.26 | 57.0 (49.0–66.0)15 | 0.03 | 0.08 |
| Transferrin saturation, % | 16.0 (12.0–27.0)7 | 24.0 (14.5–31.3)16 | 0.26 | 26.0 (16.0–47.0)15 | 0.15 | 0.51 |
| MCV, fl | 83.5 (80.3–92.5)39 | 85.5 (82.0–93.8) | 0.53 | 88.0 (84.0–104.0) | 0.049 | 0.11 |
| MCH, pg | 29.0 (26.3–32.0)39 | 29.0 (28.0–32.0) | 0.98 | 30.0 (28.0–35.0) | 0.14 | 0.14 |
Data depicted are median with interquartile range (IQR). TB, tuberculosis; TIBC, total iron binding capacity; sTfR, soluble transferrin receptor; MCV, mean cell volume; MCH, mean cell hemoglobin.
Numbers of samples available in each group is shown in superscript after the IQR if less than total number.
Cases group: HIV-infected patients diagnosed with tuberculosis (TB) more than 1 month after initial visit. Matched controls: HIV-infected patients without diagnosis of TB before or after initial visit, matched for age, gender and CD4 cell count to cases group. Unmatched controls: HIV-infected patients without diagnosis of TB before or after initial visit not matched for age, gender and CD4 cell count to cases group. P values were determined for b difference between matched controls and cases by using the Wilcoxon signed-rank test and c between unmatched controls and cases and d matched and unmatched controls by using the Mann-Whitney test.