Table 1. Increase in eicosanoid levels during lung tumor progression in orthotopic lung cancer model in mice.

analyte	Fold increase in 3 wk tumors over control	FDR (adj. p-value)
LTB4	ND	0.218
PGE2	45.2	0.009*
LTC4	13.5	0.212
LTE4	11.9	0.009*
PGD2	10.9	0.010*
TXB2	9.4	0.010*
AA	7.8	0.009*
PGF2a	4.0	0.065
12HETE	3.8	0.010*
15HETE	3.6	0.009*
5HETE	3.0	0.263
DHA	2.8	0.009*
5-oxo-ete	2.4	0.182
LTD4	1.8	0.263
6kPGF1a	0.7	0.699

Wild-type C57B/L mice were injected in left lung lobe with LLC-Luc cells. Whole left lung lobes containing tumors were harvested at 2 and at 3 weeks after injection, along with left lobes from control mice injected with PBS/Matrigel. Eicosanoids extracted from the harvested lungs were analyzed by LC/MS/MS and normalized to the protein content of the sample. Numbers in the table indicate fold increase in 3-week tumor bearing lung vs. matrigel-injected lung. ND – fold increase was not determined for LTB4, since in control mice this analyte was not detectable. * FDR<0.05