Table 2. Univariate survival analysis of clinical parameters and HA-family members expressions.

Parameters	Hazard ratio	95% confidence interval	P-value
UICC Stage	1.87	1.17 - 2.99	0.009
Largest tumor diameter	1.00	0.97 - 1.04	0.911
Histological grade	0.90	0.51 - 1.56	0.694
Age(> 75 years)	0.576	0.268 - 1.237	0.157
Gender(M)	1.36	0.76 - 2.44	0.302
Chemotherapy(+)	0.700	0.382 - 1.284	0.249
Residual tumor category(+)	2.77	1.43 - 5.37	0.003
Lymph node metastasis(+)	1.26	0.71 - 2.24	0.438
Lymphatic invasion(+)	2.27	0.54 - 9.52	0.261
Vessel invasion(+)	1.13	0.59 - 2.14	0.713
Neural invasion(+)	2.19	0.78 - 6.13	0.135
Strong HA expression	3.49	1.27 - 9.61	0.016
Strong HAS2 expression	2.47	1.12 - 5.45	0.026
Weak HYAL1 expression	2.81	1.51 - 5.22	0.001