Table 2.
Spearman’s Rank Correlation Between Study Characteristics and Placebo Response Using the Endpoint Percent Days Abstinent.
Naltrexone (n = 23) | Acamprosate (n = 15) | |||
---|---|---|---|---|
| ||||
Characteristics | rs | p-value | rs | p-value |
Duration of treatment (weeks) | −0.12 | 0.59 | −0.37 | 0.17 |
Publication year | −0.18 | 0.41 | 0.57 | 0.03 |
Mean age of participants | −0.42 | 0.05 | 0.39 | 0.15 |
% Male | −0.04 | 0.85 | −0.12 | 0.67 |
Number of sites | −0.22 | 0.31 | 0.35 | 0.20 |
Note: each of two trials involving both naltrexone and acamprosate treatment arms was treated as two separate trials in the analysis.