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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Bone Miner Res. 2014 Jan;29(1):10.1002/jbmr.2007. doi: 10.1002/jbmr.2007

Figure 2. Deletion of Bax with OCN-Cre reduces osteoblast and osteocyte apoptosis and increases femoral cancellous bone mass.

Figure 2

Histomorphometric determination of cancellous osteoblast (Ob) apoptosis, and cortical osteocyte (Ot) apoptosis (A); as well as cancellous osteoblast number (B), cancellous bone area (C), and osteocyte density (D) in femoral sections from 8-month-old male mice, n=4–5/group. (E) Representative micro-CT images of femora from BakΔBaxf/f and BakΔBaxΔOCN littermates; scale bar, 1 mm. Micro-CT was used to image and quantify femoral bone from 3-month-old mice comprising 2 males and 4 females of each genotype, 8-month-old male mice, and 22-month-old female mice. Micro-CT determination of trabecular bone volume (BV/TV) (F), trabecular number (Tb.N) (G), trabecular separation (Tb.Sp) (H), trabecular thickness (Tb.Th) (I) and connectivity density (Conn.D) (J) in the distal metaphysis of femora from BakΔBaxf/f mice at 3 months (n=6), 8 months (n = 7) or 22 months (n = 8) of age; and from BakΔBaxΔOCN mice at 3 months (n = 6) , 8 months (n = 5) or 22 months (n = 9). *p <0.05 vs. BakΔBaxf/f littermates.

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