Figure 3. Deletion of Bak and Bax with Osx1-Cre increases femoral cancellous bone mass.
(A) Representative micro-CT images from BakΔBaxΔOsx1 and BakΔOsx1-Cre littermates at 7 months of age in males, and at 21 months of age in females. Scale bar, 1mm. Micro-CT determination of trabecular bone volume (BV/TV) (B), trabecular number (Tb.N) (C), trabecular separation (Tb.Sp) (D), trabecular thickness (Tb.Th) (E) and connectivity density (Conn.D) (F) in the distal metaphysis of femora from BakΔOsx1-Cre mice at 7 months of age (n = 9) and 21 months of age (n = 7); and BakΔOsx1-Cre mice at 7 months of age (n = 8) and 21 months of age (n = 9). *p<0.05 vs. BakΔOsx1-Cre littermates.