Figure 5. Increased cortical porosity of aged Bak^ΔBax^ΔOCN mice is restricted to the endosteal zone.

Representative BSEM images of the femoral diaphyseal cortex from (A) a 22-month-old female Bak^Δ mouse, and (B) a 22-month-old female Bak^ΔBax^ΔOCN mouse. Endosteal (“E”) and periosteal (“P”) zones are separated by a highly mineralized boundary, indicated by green arrowheads. Red arrowheads mark highly mineralized cement lines that reflect previous remodeling activity. Red arrows denote areas of recently remodeled bone that have not yet achieved full mineralization.