Table 2.
Increased intracortical bone engaged in remodeling in aged BakΔBaxΔOCN mice.
| Intracortical | Cancellous | |||
|---|---|---|---|---|
| controls | BakΔBaxΔOCN | controls | BakΔBaxΔOCN | |
| B.Pm (mm)* | 11.4 ± 7.2 | 42.3 ± 13.4a | 3.13 ± 1.55 | 17.6 ± 8.4a |
| Vo.Ar/EZ.Ar | 0.10 ± 0.10 | 0.33 ± 0.22a | - | - |
| B.Ar/T.Ar | - | - | 0.012 ± 0.006 | 0.061 ± 0.037a |
| Oc.Pm (mm)* | 0.47 ± 0.38 | 1.48 ± 0.80a | 0.19 ± 0.26 | 0.89 ± 1.21 |
| Oc.Pm/B.Pm | 0.036 ± 0.024 | 0.034 ± 0.012 | 0.055 ± 0.050 | 0.037 ± 0.038 |
| Oc.N/B.Pm (/mm) | 1.15 ± 0.75 | 1.10 ± 0.49 | 2.25 ± 2.13 | 1.65 ± 1.85 |
| M.Pm/B.Pm | 0.24 ± 0.08 | 0.21 ± 0.02 | 0.22 ± 0.06 | 0.17 ± 0.06 |
| MAR (µm/d) | 1.64 ± 0.20 | 1.28 ± 0.22 | 1.34 ± 0.24 | 1.23 ± 0.09 |
| BFR/BS (µm2/µm/d) | 0.34 ± 0.08 | 0.25 ± 0.06 | 0.30 ± 0.12 | 0.20 ± 0.08 |
B.Pm = bone perimeter; Vo.Ar/EZ.Ar = intracortical void area fraction of endosteal zone area; B.Ar/T.Ar = cancellous bone fraction of tissue area; Oc.Pm = osteoclast perimeter; Oc.Pm/B.Pm = osteoclast perimeter fraction of bone perimeter; Oc.N/B.Pm = osteoclast number per bone perimeter; M.Pm/B.Pm = mineralizing fraction of bone perimeter; MAR = mineral apposition rate; BFR/BS = bone formation rate.
*
These measurements are unadjusted values, used here to indicate the increased perimeter available in BakΔBaxΔOCN mice. Data from female BakΔBaxΔOCN mice (n = 6) and combined female littermate controls (n = 9) are shown;
a
p<0.05 vs. controls.