Table 3. Significantly regulated cell populations in the lenalidomide monotherapy arm.

		C2D1 versus C1D1		C3D1 versus C1D1
		FDR adjusted p-value	FC	FDR adjusted p-value	FC
T cells	Abs total naïve T helper cells	<0.0001	−4.02	0.0743	−2.33
	% Total naïve T helper cells	<0.0001	−3	0.0094	−2.13
	Abs activated T helper cells	0.0135	1.78	0.644	1.28
	% Activated T helper cells	<0.0001	2.65	0.0231	1.81
	Abs activated T cytotoxic cells	0.0226	1.58	0.436	1.42
	% Activated T cytotoxic cells	<0.0001	1.91	0.0094	1.75
	Abs total naïve T cytotoxic cells	0.0008	−2.16	0.227	−1.64
	% Total naïve T cytotoxic cells	0.0001	−1.6	0.0511	−1.49
	Abs effector T helper cells	0.0025	−3.17	0.0094	−6.85
	% Effector T helper cells	0.0181	−2.32	0.0147	−5.5
	Abs effector T cytotoxic cells	0.0099	−1.56	0.129	−1.64
	% Effector T cytotoxic cells	0.0005	−1.31	0.0263	−1.34
	Abs total memory T cytotoxic cells	0.0242	1.51	0.162	1.66
	% Total memory T cytotoxic cells	0.0002	2.08	0.0545	1.87
	Abs effector memory T cytotoxic cells	0.035	1.71	0.812	1.19
	% Effector memory T cytotoxic cells	0.0013	2.08	0.38	1.48
	% T cytotoxic cells	0.017	1.13	0.812	1.04
	Abs T regulatory cells*	0.0047	2.28	0.0094	5.61
	% T regulatory cells*	0.0018	4.4	0.0094	12.1
	Abs T helper cells*	0.0199	−1.49	0.812	−1.1
	Abs total T cells*	0.0318	−1.38	0.812	−1.08
B cells	Abs B cells	0.0001	−3.41	0.191	−1.93
	% B cells	<0.0001	−2.59	0.116	−1.78
NK cells	% NK cells*	0.0318	1.4	1	−1.01
Lymphocytes	Abs lymphocytes	0.0378	−1.36	0.812	−1.1

^*Cell populations that are unique to the lenalidomide monotherapy arm only.

Abs, absolute; C1D1, cycle 1 day 1; C2D1, cycle 2 day 1; C3D1, cycle 3 day 1; FC, fold change; NK, natural killer.