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. 2013 Nov 11;8(11):e81121. doi: 10.1371/journal.pone.0081121

Figure 3. RAM training induces differential PKMζ and GluA2 expression between sexes in the hippocampus.

Figure 3

(A) Cytosolic PKMζ levels showed significant sex, training and retention period effects. In the post-hoc analysis, both males and females trained for 60 trials and tested 30d later showed a significant increase in cytosolic PKMζ expression compared to 60 trials / 1d test subjects. Females from both the 60 trials / 30d and 30 trial / 1 d condition showed significantly higher levels of PKMζ compared to males of the same conditions. (B) Synaptic PKMζ levels showed significant sex and training effects. Across all conditions males show significantly higher levels of synaptic PKMζ compared to females. (C) Synaptic GluA2 levels showed significant training and retention period effects. In addition, females trained for 60 trials and tested 30d later showed a significant decrease in GluA2 expression compared to 60 trials / 1d test females. For all graphs, pound (#) denotes significant sex difference compared to females in the same training/testing condition. Asterisk (*) denotes significance compared to same-sex counterparts in the 60 trial / 1d test condition.