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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Cancer Treat Rev. 2013 Aug 13;40(1):10.1016/j.ctrv.2013.08.003. doi: 10.1016/j.ctrv.2013.08.003

Figure 1. Canonical Hedgehog Signal Transduction.

Figure 1

Canonical Hedgehog signal transduction implies that the ligand, e.g., sonic hedgehog (Shh) is secreted by an epithelial cell and forms a gradient as it diffuses away from the cell. The ligand is sensed by cells in the stroma, which express Hh signaling components and primary cilia (ciliated versus non-ciliated).