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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Cancer Treat Rev. 2013 Jul 5;40(1):10.1016/j.ctrv.2013.05.009. doi: 10.1016/j.ctrv.2013.05.009

Table 1.

Histone Acetyltransferases: Classes, Nomenclature and Substrate Specificity

NOMENCLATURE OF HUMAN HATs SUBSTRATE SPECIFICITY
OLD NEW
TYPE A
GNAT FAMILY

  • hGCN5

  • hPCAF

  • KAT2A

  • KAT2B

  • H2B, H3-K9/14/23/27, H4-K8/16

  • H3-K14, H4-K8
P300/CBP FAMILY

  • CBP

  • P300

  • KAT3A

  • KAT3B

  • H2A-K5, H2B-K12/15/20, H3-K14/18/23, H4-K5/8/12

  • H2A-K5, H2B-K12/15/20, H3-K14/18/23, H4-K5/8
MYST FAMILY

  • TAF1

  • TIP60/FLIP

  • MOZ/MYST3

  • MORF/MYST4

  • HMOF/MYST1

  • HBO1/MYST2

  • ELP3

  • KAT4

  • KAT5

  • KAT6A

  • KAT6B

  • KAT7

  • KAT8

  • KAT9

  • H3 > H4

  • H2A-K5, H3-K14, H4-K5/8/12

  • H3, H4

  • H3-14

  • H4 (-5, -8, -12) > H3

  • H4-16

  • H3
TYPE B

  • HAT1

  • KAT1

  • H4-K5/-12