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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Cancer Treat Rev. 2013 Jul 5;40(1):10.1016/j.ctrv.2013.05.009. doi: 10.1016/j.ctrv.2013.05.009

Table 3.

Histone Deacetylases: Classes, Yeast Homologs, Cofactors and Localization

HDAC CLASSES HOMOLOGY TO
YEAST DEACEYTLASE DOMAIN		 CO-
FACTOR		 LOCALIZATION
I

  • HDAC 1 & 2

  • HDAC 3, & 8

 Rpd3
81, 82 %
76, 65 %
Zn2+
Zn2+
Nucleus
Nucleus/Cytoplasm
IIa

  • HDAC 4, 5,7 & 9

 Hda1
52, 53, 51, 51 %
Zn2+
Nucleus/Cytoplasm
IIb

  • HDAC 6 & 10

 Hda1

61 & 65 %

Zn2+

Nucleus/Cytoplasm
III

  • SIRT 1, & 2

  • SIRT 3

  • SIRT 4 & 5

  • SIRT 6 & 7

Sir2

NAD+
NAD+
NAD+
NAD+

Nucleus/Cytoplasm
Mitochondria/Nucleus
Mitochondria
Nucleus
IV

  • HDAC 11

Rpd3 & Hda1
42 & 41%

Zn2+

Nucleus