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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Cancer Treat Rev. 2013 Jul 5;40(1):10.1016/j.ctrv.2013.05.009. doi: 10.1016/j.ctrv.2013.05.009

Table 4.

Histone Deacetylase Inhibitors: Specificity and Current Status.

HDACi COMPOUND NAMES HDAC SPECIFICITY STATUS REF
graphic file with name nihms-491539-t0014.jpg Vorinostat HDAC1, HDAC2,
HDAC3, HDAC6		 APPROVED 54
graphic file with name nihms-491539-t0015.jpg Romidepsin HDAC1, HDAC2,
HDAC3, HDAC8		 APPROVED 54
graphic file with name nihms-491539-t0016.jpg Panobinostat HDAC1, HDAC2,
HDAC3, HDAC6		 PHASE II 53
graphic file with name nihms-491539-t0017.jpg Valporic acid CLASS I & IIa PHASE I 65-67
graphic file with name nihms-491539-t0018.jpg Phenyl butyrate CLASS I & IIa PHASE I/II 65-67
graphic file with name nihms-491539-t0019.jpg SEN196 SIRT1 PHASE II 52
graphic file with name nihms-491539-t0020.jpg COMPOUND 6J
(R= -C4H8)		 SIRT-II IC50 = 1.0 μM 54

Red circles denotes site of side chain substitution.