Table 6.
Histone Lysine Methyl Transferases: Nomenclature and Substrate Specificity.
| NOMENCLATURE HMTs | SUBSTRATE SPECIFICITY | |
|---|---|---|
| NEW | OLD | |
| KMT1A | SUV39H1 | H3K9 (P53 at K373 by KMTIC) |
| KMT1B | SUV39H2 | |
| KMT1C | G9a | |
| KMT1D | GLP | |
| KMT1E | ESET/SETDB1 | |
| KMT1F | CLL8 | |
| KMT (2A-2F) | MLL (1-5) | H3K36 |
| KMT2G | hSET1A | |
| KMT2H | ASH | |
| KMT3A | SET2 | H3K36 |
| KMT3B | NSD1 | |
| KMT3C | SYMD2 | H3K36 P53 (K370), RB (K860) |
| KMT5A | PRESET7/8 | H4K20 |
| KMT5B | SUV4-20H1 | |
| KMT5C | SUV4-20H1 | |
| KMT6 | EZH2 | H3K27 |
| KMT7 | SET7/9 | H3K4/P53 |
| KMT8A | RIZ1 | H3K9 |
| KMT8B | PRDM9 | H3K4me3 |
| KMT8C | PRDM6 | H3K20 (+KMT1C) |
| KMT8D | PRDM8 | H3K9 |
| KMT8E | PRDM3 | |
| KMT8F | PRDM16 | |
| KMT4 | DOT1L | H3K79 |