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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Cancer Treat Rev. 2013 Jul 5;40(1):10.1016/j.ctrv.2013.05.009. doi: 10.1016/j.ctrv.2013.05.009

Table 8.

Histone Methyl Transferase Inhibitors: Specificity and Activity.

HMTi COMPOUND NAMES HMT
SPECIFICITY		 ACTIVITY
IC50 		REF
HISTONE METHYLTRANSFERASE INHIBITORS (HMTis)
graphic file with name nihms-491539-t0029.jpg SAH Non-Specific - 154
graphic file with name nihms-491539-t0030.jpg Sinefungin Non-Specific - 157
graphic file with name nihms-491539-t0031.jpg Chaetocin KMT1
KMT1A
KMT1C		 - 157,158
graphic file with name nihms-491539-t0032.jpg BIX01294 KMT1C
KMT1D		 1.7nM
0.7nM		 159
graphic file with name nihms-491539-t0033.jpg UNC-0624 KMT1C
KMT1D		 1.7nM
1.9nM		 160
graphic file with name nihms-491539-t0034.jpg UNC-0638 KMT1C
KMT1D		 15nM
19nM		 160
graphic file with name nihms-491539-t0035.jpg AMI-1 Non-Specific 9μM 165
graphic file with name nihms-491539-t0036.jpg AMI-6 PRMT1 1.4μM 165
graphic file with name nihms-491539-t0037.jpg EPZ00477 KMT4 0.4nM 166
graphic file with name nihms-491539-t0038.jpg AZ505 KMT3C 0.12μM 172

Red circles denote position where side groups (R) are substituted.