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. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Cancer Treat Rev. 2013 Jul 5;40(1):10.1016/j.ctrv.2013.05.009. doi: 10.1016/j.ctrv.2013.05.009

Table 9.

Histone Demetylases: Nomenclature and Substrate Specificity.

NOMENCLATURE HDMs		SUBSTRATE
NEW	OLD
KDM1A	LSD1/AOF2	H3K4me2/me1; H3K9me2/me (AR)
KDM1B	LSD2/AOF1	H3K4me2/me1
KDM2A	FBXL11A, JHDM1A	H3K36me2/me1
KDM2B	FBXL10B, JHDM1B	H3K36me2/me1; H3K4me3
KDM3A	JMJB1A, JHDM2A	H3K9me3/me1
KDM3B	JMJB1B, JHDM2B	H3K9me3/me1
KDM4A	JMJB2A, JHDM3A	H3K9me3/me2 H3K36me3/me2
KDM4B	JMJD2B
KDM4C	JMJD2C, GASC1
KDM4D	JMJD2D	H3K9me3/me2/me1; H3K36me3/me2
KDM4E	JMJD2E	H3K9me3/me2
KDM5A	JARID1A, RBP2	H3K4me3/me2
KDM5B	JARID1B, PLU1
KDM5C	JARID1C, SMCX
KDM5D	JARID1D, SMCY
KDM6A	UTX, MGC141941	H3K27me3/me2
KDM6B	JMJD3, KIAA1111	H3K27me3/me2; H3K9me2/me1 H4K20me1
KDM7	KIAA1718	H3K4me2/me1 H3K27m2/me1
KDM8	JMJD5/ FLJ13798	H3K36me2