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Illustration of using antibodies to enhance recovery in microdialysis. In normal microdialysis, analytes (represented by shapes) cross the membrane according to their concentration gradient. In “antibody-enhanced” microdialysis, antibody added to the perfusion fluid (“y”-shapes) results in low concentration of free analyte in the dialysate. This maintains a high concentration gradient of free analytes resulting in higher recovered total concentration. (Adapted from [23].)
