Table 2. Lung cytokine and chemokine levels.
| S. pneumoniae | D39 | D39ΔhtrA | D39Δsfp | D39ΔprtA | |
| Lung homogenate, t = 48h (pg/mL) | |||||
| IL-6 | 1689 (257 – 2864) | 174 (136 – 220) ** | 1076 (220 – 3045) | 260 (174 – 3717) | |
| TNF-α | 498 (216 – 857) | 220 (189 – 277) | 592 (229 – 1290) | 285 (171 – 805) | |
| KC | 7164 (747 – 8697) | 362 (322 – 444) ** | 3218 (659 – 7962) | 482 (300 – 8355) | |
| IL-1β | 724 (116 – 1117) | 81 (73 – 97) ** | 363 (129 – 859) | 106 (79 – 1047) | |
Mice were infected with the S. pneumoniae strain indicated (5×105 CFU) via the intranasal route and euthanized 48 hours later. Data are expressed as medians and interquartile range of 7 or 8 mice per group. ** P < 0.01 versus WT S. pneumoniae.