Figure 6. SVD analysis of HIMs.

SVD analysis is applied to HIMs of 560 αβ dimers in the structural collection. a. Left singular vectors U₂ - U₅. b. Left singular vector U₁. This can be considered as the average of all 560 HIMs. c - e. Scatter plots of the first four dimensions of SVD. For example, each value of w ₂V₂ indicates how much composition of U₂ is required by an HIM. Dimers are labeled by small typeface as much as possible if the labeling is not interfering with other graphing, and are only visible on a digital copy. The continuous color scheme is identical to that in Figure 2. Structures of human and non-human Hb are indicated by solid dots and diamonds, respectively.