Table 1. The consequence of LUDLU-1 somatic substitutions.

Consequence/Type	Variants	Transcripts affected	Genes affected
STOP_LOST	1	2	1
STOP_GAINED	3	4	3
UPSTREAM (5′+5 kb)	2100	3090	1749
DOWNSTREAM (3′+5 kb)	2202	3140	1822
SYNONYMOUS_CODING	52	149	44
NON_SYNONYMOUS_CODING	106	267	89
SPLICE_SITE 1–3 bps into an exon or 3–8 bps into an intron	19	48	21
ESSENTIAL_SPLICE_SITE First or last 2 bps of an intron	6	29	6
3′UTR	137	229	126
5′UTR	47	70	43
INTRONIC	11021	15822	4109
INTERGENIC	17642	NA	NA