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Effect of 4-AP, a Kv inhibitor, on PAP and HPV (ΔPAPHypoxia) in control and 2d-H rats. (A, B) Representative traces of PAP recording in control and 2d-H rats. Both basal PAP and ΔPAPHypoxia were increased by 5 mM 4-AP in control (A). In 2d-H, however, basal PAP was slightly increased by 4-AP, and ΔPAPHypoxia was not recovered by the 4-AP pretreatment (B). (C) Summaries of the results shown as bar graphs (n=5; control, n=4; 2d-H, **p<0.01).
