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. 2013 Nov 11;8(11):e78938. doi: 10.1371/journal.pone.0078938

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© 2013 Pachel et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) TWEAK and (B) Fn14 mRNA expression were significantly increased 3 days after experimental MI. Fn14 mRNA expression was significantly increased after 8 weeks of MI. (C) Immunohistological staining after 3 day of MI revealed high expression of Fn14 protein in the border zone of the myocardium co-localizing with periostin expression. (D) Periostin positive fibroblasts are the main source of Fn14 expression in the infarcted heart and αSAA positive cardiomyocytes show no expression of Fn14. (E) Isolated cardiac mouse fibroblasts express Fn14 whereas (F) isolated cardiomyocytes show no Fn14 expression.