Table 1. HSA-Flag-TWEAK does not affect echocardiographic measurements after MI.
| Parameter | PBS, sham | HSA-Flag-TWEAK, sham | PBS, MI | HSA-Flag-TWEAK, MI |
| Day 1 | ||||
| n | 3 | 3 | 9 | 17 |
| Heart rate (bpm) | 473±19 | 440±15 | 462±29 | 495±16 |
| Papillary | ||||
| ESA (mm2) | 7±0.4 | 5.7±0.3 | 12.2±0.7 | 11.7±0.5 |
| EDA (mm2) | 10±0.8 | 7.6±0.4 | 14.5±0.5 | 14.2±0.6 |
| 2D FS (%) | 29.6±3.0 | 25±0 | 16.1±2.5 | 17.4±1.5 |
| Apical | ||||
| ESA (mm2) | 7.6±0.4 | 7±1.0 | 13.5±0.8 | 11.9±0.7 |
| EDA (mm2) | 11.2±0.7 | 9.9±0.5 | 15.7±0.9 | 14.1±0.7 |
| 2D FS (%) | 32.3±4.9 | 29.8±6.4 | 14.1±1.7 | 15.7±1.8 |
| Day 3 | ||||
| N | 3 | 3 | 7 | 15 |
| Heart rate (bpm) | 473±3 | 480±47 | 563±23 | 561±11 |
| Papillary | ||||
| ESA (mm2) | 8±1.15 | 6.4±0.8 | 12.9±1.3 | 12.7±0.8 |
| EDA (mm2) | 10.3±1.45 | 8.7±1.2 | 15.4±1.3 | 15±0.8 |
| 2D FS (%) | 22.7±1.46 | 25.3±3.1 | 17.3±2.0 | 15.8±1.2 |
| Apical | ||||
| ESA (mm2) | 7.6±0.29 | 8.2±1.4 | 12.8±1.4 | 12.7±0.8 |
| EDA (mm2) | 10.8±0.62 | 10.9±1.7 | 15.4±1.56 | 15±0.8 |
| 2D FS (%) | 29.7±2.18 | 25±2.2 | 17.1±1.6 | 16.5±1.8 |
Animals underwent echocardiography on day 1, day 3, day 21 (data not shown) and day 56 (data not shown) after MI. All measurements were recorded at the midpapillary level which shows changes in the dimensions of the surviving non-infarcted myocardium, as well as on the apical level depicting changes in scar formation.
Data are means ± sem; n indicates number of animals studied. EDA, end-diastolic area; ESA, end-systolic area; FS, fractional shortening; 2D, 2-dimensional.