Figure 7. Cdk4 inhibitors protect primary rat cortical neurons against Aβ induced death.

Primary rat cortical neurons (5DIV) were exposed to Aβ (1.5 µM) in presence and absence of Cdk4 inhibitors (Cdk5I1 & 8A) for 48 h. Percentage of viable cells were estimated by intact nuclear counting assay. (A) Graphical representation of percentage of viable cells. Data represented as mean ± SD of two independent experiments. The asterisks denote statistically significant differences between indicated class:*p<0.05. (B) Representative phrase contrast micrographs show retention of neuronal processes in presence of Aβ by Cdk4 inhibitors.