Figure 11. Cdk4 inhibitors block elevation of Bim and active caspase3 levels in response to NGF deprivation in neuronal PC12 cells.

Cells were subjected to NGF deprivation in presence and absence of Cdk4 inhibitors for 20(A) Representative immunoblot showing reduction in NGF deprivation induced Bim level by Cdk4 inhibitors (Cdk4I1 & Cdk4I2). (B) Representative images of immunostained cells. Result shows Cdk4 inhibitors (Cdk4I1 & 8A) effectively blocks NGF deprivation induced elevation of active caspase3 level.