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. 2013 Nov 11;203(3):457–470. doi: 10.1083/jcb.201302092

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© 2013 Mosammaparast et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — LSD1 promotes 53BP1 IRIF formation in late S/G2 cells. (a) LSD1 affects 53BP1 foci formation in a subset of cells but does not affect pH2A.X or MDC1 foci formation. U2OS cells were infected with the indicated lentiviral shRNAs, exposed to 10 Gy IR, incubated at 37°C for 1 h, and processed for immunofluorescence using the indicated antibodies. (b) U2OS-FUCCI cells were infected with the indicated lentiviral shRNAs, exposed to 10 Gy IR, incubated at 37°C for 1 h, and processed for immunofluorescence using an antibody against 53BP1. Bars, 20 µm. (c) The experiment in panel b was performed in triplicate, and 53BP1 foci were quantified as shown. Error bars represent ± SD. *, P < 0.01; n.s., not significant.